Rome, once mighty, lies in ruins. The city swarms with suffering and degradation, her citizens living in the shadow of the ruthless Borgia family. Only one man can free the people from the Borgia tyranny—Ezio Auditore, the master assassin.

Ezio's quest will test him to his limits. Cesare Borgia, a man more villainous and dangerous than his father, the Pope, will not rest until he has conquered Italy. And in such treacherous times, conspiracy is everywhere—even within the ranks of the Brotherhood itself.