Jimmy Veeder has finally settled down, completing his dramatic transformation from hell-raiser to family man. With his new wife, Angie, and eight-year-old son, Juan, he lives the quiet life. No trouble, no problems.

Or so he thought. But this is Jimmy Veeder's Fiasco, after all.

The night after his wedding, Jimmy is lured right back into a world of danger and mayhem when childhood friend Tomás Morales, the current crime lord of Mexicali, turns up on his doorstep offering information about the whereabouts of his son's grandfather, for whom Jimmy has been searching for years.

Jimmy and Angie head to Mexico—one part honeymoon, one part expedition to find Juan's grandfather—accompanied by old pals Bobby Maves and Griselda.

The trip immediately careens into chaos when they find themselves shadowed by thugs, shot at by cartel soldiers, and forced into a confrontation with a violent, volatile drug lord. The fight spreads from Sinaloa back to Jimmy's doorstep, putting everything Jimmy cares about directly in the crosshairs.